Beilstein J. Org. Chem.2018,14, 2949–2955, doi:10.3762/bjoc.14.274
vinyl ethers as key step of reaction sequences developed.
Keywords: 3-aminoglycals; diastereoselective additions to aldehydes; pluramycins; ring-closing metathesis; vinyl ethers; Introduction
Several classes of medicinally useful molecules with antibiotic and anticancer activity contain in their
for access to 3-aminoglycals.
Synthesis of key intermediate 23 for the C-3 unbranched amino glycals preparation.
Access to diastereoisomeric compounds 3 and 4 from 23.
Supporting Information
Supporting Information contains detailed experimental procedures with full characterization of all compounds
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Graphical Abstract
Figure 1: N,N-Dimethyl-L-vancosamine as substructure of kidamycin and pluramycin.